Hesperidin Extract

Shaanxi Rebecca Biotechnology Co., Ltd is a high purity plant extracts manufacturer with sophisticated processing ability.

In our facilities we use high temperature drying and ultra-fine grinding technology to ensure the nutritional integrity of botanical materials. With the help of the most advanced testing equipment, we have a full quality control system to make sure each batch of product is up to international standards including ISO9001, HALAL, KOSHER, cGMP, and HACCP certifications.

Our excellent supply capacity can support small scale trial orders as well as big volume commercial production.

You are able to get versatile OEM/ODM customisation services for your individual formulation needs.

We can assure quick delivery with our best supply chain management and global logistics network.

We have several shipping alternatives such as FedEx, DHL, air freight or sea transport. So, wherever you are your product will reach you securely.

The basic materials are ripe peels of citrus fruits of the Rutaceae family, mainly sweet oranges, navel oranges and mandarins. The white pith layer is the optimum substrate for extraction since it has the highest concentration of natural hesperidin. Our suppliers grow citrus in regulated circumstances where they can maintain soil pH between 6.0-7.5 to ensure optimal concentration of active chemicals.

For each batch, we maintain complete traceability paperwork from harvest to processing. We have stringent sorting techniques that ensure the removal of contaminants, seeds and damaged material prior to any extraction taking place. This methodical approach provides you with consistent quality and full supply chain transparency for your regulatory compliance demands.

Standard product powder has little solubility in cold water but is soluble in dilute alkaline solutions, methanol and ethanol. We have developed cyclodextrin-modified versions for increased water dispersibility, which dissolve quickly in cold and hot water and avoid precipitation in liquid formulations.

Temperature stability is still quite good up to 65°C, however after a long time above 80°C oxidation and discolouration can occur. The ideal pH window for long-term stability is 4.0-7.5, with high acidity causing crystallisation and strong alkalinity causing deterioration. The dry powder is stable for up to 24 months in sealed, light-protected containers. UV protection is required for aqueous solutions to prevent loss of oxidative action.

We start our extraction by carefully sorting and washing citrus peels and then drying them at low temperatures (40-45 °C) to protect the bioactive chemicals. The dried material is ground to a 20-30 mesh size, to give optimum surface area for solvent contact. For the more demanding criteria we use ethanol procedures for cleaner extracts. We use dilute alkaline water extraction or ethanol-water reflux extraction depending on the purity targets.

After extraction, the pH is adjusted to cause crystallisation, which allows separation of the crude hesperidin from water-soluble contaminants. The filtrate was then vacuum concentrated at low temperature below 65 °C to avoid thermal damage. The key phase of purification is adsorption on macroporous resin; for a product with 98% purity, multi-stage cascade resin systems with gradient elution using ethanol are used.

Secondary concentration and decolorisation with activated carbon precede recrystallisation to remove oxidised chemicals. High purity grades are subjected for two gradient recrystallisations to remove maximum impurity. The crystals are washed, centrifuged to remove water and then hoover dried in the dark. For water soluble variations we employ cyclodextrin inclusion modification. Final procedures are grinding to specification, full batch blending and vacuum sealed packaging in aluminium foil bags in moisture-proof cardboard drums

Hesperidin Extract is used by pharmaceutical producers that manufacture drugs for venous health, primarily for the treatment of haemorrhoids and varicose vein management. It is a precursor of Diosmin and is the basis for micronised pure flavonoid fractions given for the improvement of microcirculation.

This extract improves cutaneous microcirculation for cosmeceutical treatments, decreases undereye darkness and boosts skin brightness by inhibition of tyrosinase. Its hydrophilic nature limits skin penetration thus formulators encapsulate it in liposomes to overcome this problem. It is used by sports nutrition manufacturers for its insulin-sensitizing and antioxidant characteristics that help protect against exercise-induced oxidative damage. It is compatible with caffeine and probiotic compounds for metabolic support supplements and survives high compression tableting without degradation.

Each production lot is tested completely for content, physicochemical qualities, heavy metals, pesticide residues and microbiological safety. Our quality control processes meet EU EC396 and EU 2023/915 requirements and we can provide third party laboratory verification on request. We provide full traceability and regulatory compliance paperwork to satisfy your need for supply chain transparency and validation.

Standard packing is vacuum sealed aluminium foil inner packs, protected by 25kg moisture-proof cardboard drum. This two-layer technique efficiently protects the product against air, moisture and light contamination. We may provide custom packaging solutions for trial amounts as tiny as needed for formulation testing, and even branded packaging for white-label setups. Shipping: FedEx, DHL or other express shipping companies, air freight for urgent orders, sea freight for huge volumes at low cost.

Q: Will your water-soluble modified grade prevent precipitation in acidic beverages?

A: Yes, our cyclodextrin inclusion hesperidin considerably increases the cold water solubility and inhibits precipitation even in low pH long term storage liquid formulations.

Q: How do you reduce batch-to-batch variation for colour and content?

A: Narrow tolerance ranges are achieved using a uniform raw material procurement, standardised decolorisation processes, several recrystallisation phases and finished batch mixing.

Q: Do you supply tiny samples for formulation testing before big orders?

A: Yeah, sure. We can be flexible on MOQ and can provide either paid or complimentary samples for your lab stability trials prior to going into production volumes.

Q: How do you stabilize raw material supply during seasonal fluctuations?

A: We stock qualified fresh peels during harvest season using low-temperature drying and sealed storage systems, maintaining annual reserves that enable stable quarterly pricing for long-term contracts.

Q: What shipping documentation do you provide for customs clearance?

A: Complete export documentation comprises a Certificate of Analysis, MSDS, phytosanitary certifications, and any regulatory compliance certificates necessary by your destination country.

contact us today for detailed specifications, custom formulation support, or sample requests for Hesperidin Extract: information@sxrebecca.com

Hesperidin Extract Product Introduction

At Shaanxi Rebecca Bio-Tech Co., Ltd., we are dedicated to promoting human health through our range of high-quality plant-based products. Our Hesperidin Extract is derived from natural citrus fruits using advanced extraction techniques, preserving the beneficial compounds that promote health and wellness. With a commitment to excellence, we bring you an extract known for its antioxidant, anti-inflammatory, and vascular-protective properties.

Specifications

Hesperidin, also known as dihydroflavonol glycoside, has a molecular formula of C28H34O15 and a density of 1.65 g/cm3. This product is a white or light yellow crystalline powder; Odorless and tasteless. Soluble in pyridine or dimethylformamide, insoluble in ethanol or water.

Purpose

1. Can be used as a nutritional fortifier.
2. Hesperetin has vitamin P-like efficacy and can be used in skin care products to prevent frostbite. It can resist inflammation and viruses, and has a certain antibacterial effect. When used in oral hygiene products, it can inhibit the formation of dental plaque and reduce bad breath at the same time. Can prevent UV radiation and can be used for sunscreen products

Effect of hesperidin

1. Vitamin drugs can reduce the fragility of capillaries, protect capillaries, and prevent microvascular rupture and bleeding. Used as an adjuvant therapy for hypertension
2. This product is a vitamin P medication used to enhance the toughness of capillaries.

Pharmacological action

1. Enhance venous tone by prolonging the vasoconstriction time induced by noradrenaline (this effect still exists in fever and acidosis).
2. Reduce the adhesion and migration between white blood cells and endothelial cells, decrease the release of inflammatory substances (such as histamine, bradykinin, complement, leukotrienes, prostaglandins, excessive free radicals, etc.) after disintegration, thereby reducing capillary permeability.
3. Reduce blood viscosity, increase blood flow rate, and thus improve microcirculation stasis.
4. Improve lymphatic circulation, accelerate tissue fluid reflux, and reduce edema. Diosmin/hesperidin is used for hemorrhoids, which can alleviate the acute symptoms of hemorrhoids, as well as reduce their frequency and duration of attacks

Application Areas

Hesperidin Extract finds wide applications in:

• Pharmaceuticals: Used for its antioxidant and anti-inflammatory properties to support cardiovascular health and venous function.
• Nutritional Supplements: Incorporated into products aimed at enhancing capillary health, reducing inflammation, and improving immune function.
• Cosmetic Industry: Utilized for its skin-soothing and anti-aging properties.
• Food and Beverage: As a functional ingredient for health-promoting properties.

Production Process

1. Raw Material Selection: High-quality citrus fruits are chosen as the raw material source.
2. Extraction: Utilizing a high-efficiency extraction process to isolate and concentrate the active compounds.
3. Filtration and Purification: Removing impurities to ensure the highest product quality.
4. Drying: Employing low-temperature drying techniques to preserve the potency and natural properties.
5. Grinding and Sieving: Achieving the desired particle size for ease of use.
6. Final Quality Control: Comprehensive testing and certification to ensure product compliance with industry standards.

Quality Control

Shaanxi Rebecca Bio-Tech Co., Ltd. maintains a stringent Quality Control system at every production stage. Our facility is equipped with advanced testing instruments, ensuring the highest product purity, stability, and consistency.

Packaging and Transportation

• Packaging: 25 kg/drum or customized packaging per client requirements.
• Storage: Recommended storage in a cool, dry place.
• Transportation: Sealed packaging ensures the product's integrity during transit.

Shipping Samples

We offer samples to our valued customers for testing and evaluation, ensuring confidence in our product quality and performance.

After-Sales Service

Our dedicated customer support team offers comprehensive after-sales service, including technical assistance, product guidance, and timely responses to inquiries.

Qualification Certification

Our Hesperidin Extract is manufactured in a facility adhering to GMP standards, ensuring quality, safety, and compliance with global regulatory requirements.

Frequently Asked Questions (FAQ)

1. What is Hesperidin Extract used for?
   • Hesperidin Extract is commonly used in supplements, cosmetics, and pharmaceuticals for its health-promoting and protective properties.
2. Is your product tested for contaminants?
   • Yes, each batch undergoes rigorous testing for heavy metals, microbiological contaminants, and other impurities.
3. Can I get a sample before placing a bulk order?
   • Absolutely! We offer samples to help you evaluate our product's quality.

Contact us

At Shaanxi Rebecca Bio-Tech Co., Ltd., we are dedicated to providing the Hesperidin Extract to meet the needs of the pharmaceutical, biotechnology, and related industries. If you’re looking for a reliable supplier with high-quality standards, flexible packaging options, and excellent customer service, feel free to contact us at information@sxrebecca.com for more information.