CAS No.:1077-28-7
Specification:99%
Test Method:HPLC
Appearance:Light yellow to yellow powder
Water soluble:Low solubility in water, about 1 g/L (20°C)
Function:Antioxidants and enzymes such as pyruvate dehydrogenase.
Application:Health care and medicine.
Function:For acute and chronic hepatitis, cirrhosis etc.
Application:Used in Vitamin drug and health care products.
Solubility:Soluble in 10% NaOH solution, soluble in aliphatic solvent. Soluble in methanol, ethanol, chloroform, ether.The solubility in water is small, about 1 g/L (20°C).
- Product Description
A Lipoic Acid Powder: Premium Antioxidant Solution for Advanced Formulations
Alpha lipoic acid is a breakthrough chemical in the field of nutritional biochemistry and skin care. This organosulfur compound is both a strong antioxidant and a crucial cofactor in cellular energy production. A Lipoic Acid Powder from Shaanxi Rebecca Biotechnology delivers pharmaceutical-grade purity at 99% minimum, offering formulators a stable, bioavailable ingredient for metabolic support and anti-aging applications. The compound’s unique amphipathic nature allows it to penetrate cell membranes, offering broad protection against oxidation in aqueous and lipid environments. It can also recycle other antioxidants such as vitamin C and vitamin E, generating synergistic effects that boost the overall efficacy of the product and so benefit your formulations.
Technical Specifications
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Parameter |
Specification |
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English Name |
α-Lipoic Acid |
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Alternative Name |
1,2-Dithiolane-3-pentanoic acid |
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CAS Number |
1077-28-7 |
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Molecular Formula |
C8H14O2S2 |
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Molecular Weight |
206.33 |
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Active Ingredient |
α-Lipoic Acid |
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Purity |
Min 99%, HPLC |
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Appearance |
Light Yellow Powder |
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Particle Size |
80 Mesh |
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Test Method |
HPLC |
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Certifications |
ISO9001, HALAL, KOSHER, HACCP, Non-GMO, Vegan |
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| Test Item | Specification | Result | Test Method |
|---|---|---|---|
| Appearance | Yellow crystalline powder | Complies | Visual Inspection |
| Identification | IR spectrum conforms to reference standard | Positive | IR‑Spectroscopy |
| Assay (on dry basis) | 99.0%‑101.0 % | 99.6 % | HPLC |
| Loss on Drying | ≤ 0.5 % | 0.23 % | Vacuum Drying |
| Melting Point | 58.0 ℃‑62.0 ℃ | 59.7 ℃ | Capillary Method |
| Heavy Metals | |||
| ‑Lead (Pb) | ≤ 10 ppm | < 2 ppm | ICP‑MS |
| ‑Arsenic (As) | ≤ 2 ppm | < 0.5 ppm | ICP‑MS |
| ‑Cadmium (Cd) | ≤ 2 ppm | < 0.5 ppm | ICP‑MS |
| ‑Mercury (Hg) | ≤ 1 ppm | < 0.1 ppm | ICP‑MS |
| Related Substances‑Single Impurity | ≤ 0.2 % | 0.09 % | HPLC |
| Related Substances‑Total Impurity | ≤ 0.5 % | 0.21 % | HPLC |
| Residual Solvents | Meet ICH‑Q3C Requirements | Complies | Headspace‑GC |
| Ash (Sulfated) | ≤ 0.1 % | 0.05 % | Gravimetry |
Why Choose Us?
Shaanxi Rebecca Biotechnology is famous for strict quality processes and customer-oriented flexibility. We’re serious about testing and ensure purity, potency and heavy metal compliance before shipment to boost your supply chain. We create two grades of food-grade and cosmetic-grade products that have distinct standards of microbiological control to meet your regulatory needs.
We have the technological ability to provide unique formulation services. Ready stock is available in 99% DL-type racemic mixtures, 99% R-isomer for increased bioactivity or 99.5% ultra-pure grades. Particle sizing options include normal 80-100 mesh for tablet compression and 200 mesh super fine powder for beverage dispersions.
The logistics competence that ensures your orders arrive unharmed. We use nitrogen packed vacuum packing with double layer light shielding to avoid Oxidative yellowing during in transit. High temperature and humidity accelerated stability testing . Shelf life performance confirmed . Detailed reports available upon request .

Production Process
A Lipoic Acid Powder manufacturing begins with precision chemical synthesis under controlled atmospheric conditions. Raw materials are subjected to rigorous identity tests including spectroscopy to check molecular conformity integrity.
The synthesis route incorporates cyclisation processes under controlled temperature conditions followed by crystallisation steps to attain the desired purity levels. Trace impurities and associated compounds are removed below detection thresholds by multiple recrystallisation cycles.
Advanced HPLC analysis checks every batch of production. Chromatographic separation is used to identify and quantify the active molecule and to detect any breakdown products. This level of analytical rigour ensures conformity with the USP and EP monograph criteria.
Final powder is jet milled. Optimising dissolving rates and blending consistency in your downstream processing is achieved through controlled particle size distribution. Grinding is done under nitrogen blanket to avoid oxidative exposure.
Heavy metals testing by ICP-MS, microbiological testing against pharmacopeial limits and residual solvents analysis by gas chromatography are part of quality assurance. Only those batches that satisfy all the standards are packaged under inert gas protection in oxygen-barrier materials.

Application Fields
Dietary Supplements: Alpha lipoic acid helps regulate glucose and improve insulin sensitivity, which benefits your metabolic support formulations. The chemical aids mitochondrial activity in anti-fatigue sports nutrition products. Liver health supplements incorporate it for antioxidant protection during detoxification processes.
Cosmetic Innovation: Product is used in anti-glycation serums by skincare formulators to prevent the crosslinking of proteins that causes skin stiffness. Its metal-chelating characteristics neutralise free radical catalysts in anti-photoaging creams. The chemical has an anti-inflammatory profile and is suited to sensitive skin formulations addressing redness.
Research Applications: Laboratory scientists want pharmaceutical-grade material for cell culture research of oxidative stress pathways. It is used by biomedical researchers as a reference standard for development of analytical methods.

Packaging & Delivery
We understand that oxidative stability is the key to product success, and we have developed extensive packaging solutions. Primary containers are pharmaceutical grade aluminium foil bags with heat sealed sealing. The interior packages are nitrogen flushed to remove oxygen prior to sealing creating an inert atmosphere to protect antioxidant activity .
Mechanical protection is obtained using fibre drums with moisture-barrier liners as secondary packaging for overseas shipping. Each barrel contains desiccant packs calibrated to keep relative humidity below critical levels. External labels contain light-sensitive indications that indicate exposure to photodegradation during transit.
We ship in standard packaging sizes; 1kg aluminium bags for trial orders up to 25kg drums for production volume procurement. Custom package options to meet your inventory management needs – from subdivision into smaller units or bulk containers for automated dispensing systems.
We cooperate with temperature regulated freight carriers within our global logistics network. Shipments to tropical regions are packed in insulated packaging including phase-change materials in order to maintain a stable thermal environment. Real-time GPS tracking for supply chain visibility from our plant to your receiving port.
Every shipment comes with documentation: Certificate of Analysis with batch specific test findings, Material Safety Data Sheet, allergen declarations, and GMO-free certificates. We give drug master files and complete stability data packages for regulatory applications.
Delivery times are normally 7-15 business days for air freight to major commercial centres while ocean shipping is a cost-effective option for larger volumes. Express courier services to most destinations within 72 hours for urgent requirements.

FAQ
Q: Alpha lipoic acid is prone to oxidation during sea transport. What anti-oxidation packaging do you use?
A: We implement whole-process oxygen-isolated production plus nitrogen-filled vacuum packaging with light-proof double-layer protection. Accelerated stability test reports under high temperature and humidity conditions verify shelf-life quality maintenance.
Q: Do you separate oral food grade and cosmetic external grade with independent standards?
A: Yes, both grades feature differentiated microbial control indexes. We provide exclusive microbial test reports per batch according to your specifications.
Q: What purity grades and particle sizes are available for customization?
A: Stock options include 99% DL-type, 99% R single isomer, and 99.5% high-purity grades. Particle sizing includes 80-100 mesh and 200 mesh ultra-fine powder. Customized formulations with designated excipients proceed upon order confirmation.
Contact Us
contact us at information@sxrebecca.com to discuss your A Lipoic Acid Powder requirements. Our technical team provides formulation guidance and sample coordination for your evaluation protocols.
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