Ws 23 Cooling

Shaanxi Rebecca Biotechnology Co., Ltd. has 30 years of fine chemical synthesis experience and is well-positioned to produce cooling agents. We use activated carbon deodorisation units in combination with gradient recrystallisation systems to produce trace impurities of less than 0.1%. Our batch homogenisation procedure reduces melting point variations between manufacturing runs – crucial to ensuring constant cooling strength in your compound flavour systems.

Our R&D team developed cyclodextrin inclusion modification for aqueous applications, eliminating the crystallisation headache in transparent oral drinks. We insulate your annual contracts from the volatility of the market with quarterly raw material bulk procurement agreements, locking in nitrile feedstock cost. All batches are verified before shipment using advanced HPLC and GC testing equipment. Our ISO22000 and FSSC22000 certifications provide full traceability from beginning materials to finished drums.

The product is not plant-extracted but is the result of focused synthesis in our fine chemical production lines. Pharmaceutical-grade 2,3-Dimethyl-2-isopropylbutyronitrile is supplied by approved sources and comes with GMP compliance certificates. Each lot of raw material undergoes negative pressure distillation to eliminate polymerisation by-products before entering our synthesis reactors.

Our supply chain tracks every intermediate from the methylamine batches to the recrystallisation solvents with digital batch codes. We offer three classes of specification to suit different market segments: 98% for daily chemical applications, 99% for mainstream foods and cosmetics (our top seller satisfying FEMA and EU CosIng regulations) and 99.5% ultra-high purity for pharmaceutical references. All grades are shipped with complete analytical certifications including beginning material sources, synthesis dates and third party heavy metal testing findings.

Knowledge of the patterns of product solubility prevents formulation failures. The chemical is poorly soluble in water (≈0.7 g/L), hence it cannot be directly dispersed in water without co-solvents. Full dissolution in ethanol, propylene glycol, triacetin and MCT oil. These are the preferable carriers for vape liquids and gel formulations. Our cyclodextrin encapsulated version for water-based systems stays clear during three high-low temperature cycles with no precipitation.

The thermal stability is more than 200℃. It can still play a role in cooling while boiling sugar and baking, which will volatilise menthol. The chemical is stable over a pH range of 4.0–8.5, which covers the pH range of most beverages and cosmetics. Avoid long term exposure of strong alkalis (>80 degree C) since it slow amide hydrolysis. It’s packaged in light-protected aluminium foil to prevent discolouration from UV exposure during the 24-month shelf life. No chemical interactions were observed, however synergistic effects with WS-3 or natural menthol increased the total cooling intensity.

Our process starts with pretreatment of the beginning material. The crude nitrile feedstock is subjected to low pressure distillation to remove low boiling impurities. Simultaneous dehydration of methylamine and methanol solvents is performed to minimise hydrolysis side reactions.

The autoclave alcohololysis process involves the reaction of nitrile, anhydrous methanol and sulphuric acid catalyst in sealed reactors. TLC follows conversion rates till completion, including neutralisation and recovery of surplus methanol resulting in crude methyl butyrate intermediate.

In the amide exchange reaction, the ester is reacted with monomethylamine under controlled pressure, giving crude greasy WS-23. The excess amine is recycled and small molecule solvents are eliminated to avoid contamination for later purification.

Crude product is stripped of free amines and unreacted esters by countercurrent acid-alkali-brine washes. Residual moisture is removed with anhydrous desiccants prior to negative-pressure solvent stripping.

The final purity grades are determined at the gradient recrystallisation stage. Two-stage recrystallisation with activated carbon deodorisation attains our 99% criteria. Vacuum distilled 99.5% grade is for elimination of trace isomers. Recycling mother liquors increases yield and decreases waste.

Centrifugal washing with cold solvent to remove the surface contaminants Then low temperature vacuum drying (≤55℃) to avoid agglomeration . For water-dispersible products, a cyclodextrin inclusion branch first dissolves WS-23 in propylene glycol, and then homogenises with β-cyclodextrin solution before spray drying.

The last steps are crushing and sieving to 80-200 mesh according to customer specifications, three-dimensional batch homogenisation to reduce variances in melting point and light-proof sealed packaging in vacuum aluminium foil bags. Full GC impurity profiling and issuance of COA is performed for each batch prior to warehousing.

Ws 23 Cooling is the main ingredient in e-liquid “ice” compositions that can resist fast atomisation without clogging the coil and produce front-mouth throat impact.

Confectionery - Add throughout molten candy stages to ensure even distribution and zero flash-off losses during cooling. Chewing gum makers like the long lasting effect that is released slowly after chewing.

Topical cosmetics such as after-sun gels and cooling sunscreens are also tapping into its skin-soothing benefits to offer relief without the peppermint irritation.

In oral care products, 0.05–0.2% concentrations are used to increase mouthwash freshness and toothpaste appeal.

In flavour houses, it’s blended with other cooling agents at 20-50 ppm to generate complex sensory profiles in beverages and nutraceuticals, providing base flavour fidelity with refreshing new aspects.

Our certification portfolio includes ISO9001, ISO22000, FSSC22000, HACCP, HALAL, KOSHER and cGMP. Before release all production batches are subjected to GC purity analysis, HPLC impurity profiling and ICP-MS heavy metal screening. Our in-house results are validated quarterly by third-party labs, with reports available upon request.

Batch traceability goes back to raw material lot numbers and onwards through tracking of client deliveries. We hold 500g sample archives for 3 years so that we can retroactively investigate if there are quality problems. Our product is non-GMO and vegan compliant, which makes it acceptable for clean-label applications. Solvent residue testing verifies conformity with EU and FDA regulations.

Standard packaging is dual layer protection with inner vacuum sealed aluminium foil bags (light-proof, moisture-barrier) in 25kg fibre drums with desiccant packets. We can offer R&D volumes in 1kg, 5kg or 10kg subdivisions and bulk 500kg supersacks for the high volume consumer.

Global delivery by DHL, FedEx or sea freight depending on order size and urgency. The substance is stable, thus does not require cold chain logistics, however we do prevent exposure to high temperatures during summer transit. Lead times are 7-10 days for stock specs and 15-20 days for bespoke purity grades. All shipments will contain COA, MSDS, and customs declaration documentation.

Q: Does your cyclodextrin version pass accelerated stability tests without precipitation?

A: Yes, our β-cyclodextrin encapsulated grade withstands three high-low temperature cycles, maintaining clear dispersion in aqueous systems without crystallization or stratification—ideal for oral liquids and transparent essences.

Q: How do you control batch-to-batch cooling intensity variations?

A: Starting materials are pre-grouped by purity before processing. Standardized recrystallization protocols plus three-dimensional bulk blending keep melting point tolerance within narrow ranges, minimizing odor and cooling strength fluctuations.

Q: Can you lock pricing against raw material volatility?

A: Absolutely. We execute seasonal bulk procurement of nitrile feedstock with moisture-proof storage. Long-term clients negotiate quarterly fixed-price agreements to hedge upstream cost fluctuations and guarantee uninterrupted supply.

Q: What retention rate proves thermal advantage over menthol?

A: Our high-temperature stability reports show over 95% cooling effect retention after sustained 185℃ heating—no volatilization or bitter byproducts, perfect for hard candy and thermal filling production.

Contact our technical team at information@sxrebecca.com for sample requests, custom purity quotes, and application development support. We'll help you optimize Ws 23 Cooling dosing for your specific production environment.